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UBR7 functions with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy, ptosis, and hypothyroidism - ScienceDirect
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![Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function | PNAS Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function | PNAS](https://www.pnas.org/cms/asset/44f4a657-9ad4-42d1-8be2-2381a0b40c9e/keyimage.jpg)